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Holotomographic Microscopy – HT 1

HT-1 is a new microscope designed to let researchers view live cell using holotomograhpy technology. One of the world’s first microscopes of its kind, the HT-1 delivers non-invasive, real-time quantitative data with the highest resolution on the market today.

Holotomographic Microscopy – HT 1

Revolutionary holotomographic (3D holographic) microscopy opens new era for label-free live cell imaging

Cellular analysis plays a crucial role in a wide variety of research and diagnostic activities in the life science. However, the information available to researchers and clinicians is limited by current microscopy techniques. An innovative new tool – Holotomographic microscopy – can overcome many of these limitations and open new vistas for researchers and clinicians to understand, diagnose and treat human diseases.

Holotomographic Microscopy – New era of microscopy Tomocube’s holotomography series utilize optical diffraction tomography (ODT), which enables users to quantitatively and noninvasively investigate biological cells and thin tissues. ODT reconstructs the 3D refractive index (RI) distributions of live cells and by doing so, provides structural and chemical information about the cell including dry mass, morphology, and dynamics of the cellular membrane.


TomoStudio™, Software platform for 2D/3D/4D image analysis

TomoStudio™, HT-1 operating SW, controls the system and visualizes the captured image in various ways. This flexible user interface provides fast imaging capability and 2D/3D/4D visualization of the cellular image based on 3D RI distributions of the cells and tissues. follow this link. TomoStudio™

Smart technology for holotomography

HT-1 use holotomography technology which measures the 3D and 4D refractive index (RI) tomograms. This new technology enables quantitative, label-free measurements of live, unstained cells and tissue samples. With the dynamic micromirror device (DMD), we have eliminated moving parts from light path while image-capturing and has added unprecedented stability and precision on the outstanding performance of our product. If you want to get more information about our technology, follow this link. Technology

3-D Refractive Index:

new imaging contrast

No labeling

High resolution

Low laser

Fast in 2D/3D

High impact, Low cost

Zero stress

Label-free imaging

Intact live cell imaging
Long-term image with short time interval

Time saving
No sample preparation and Rapid 3D cell imaging

High quality 3D
Optical resolution below 200 nm (Max. 110 nm)

Quantitative bioimaging
RI enables quantitative bioimaging
(local cytoplasmic concentration, dry mass)