Archives: Product

Photon etc-NIR-II Preclinical Imager

Imaging in the Second Biological Window

IR VIVO is an infrared multispectral imager for small animal studies. This system benefits from reduced light scattering, absorption and auto-fluorescence by using a detection system in the near and short-wave infrared. Visualize your biomarkers in vivo  and in real-time with optimized contrast resolution and sensitivity. IR VIVO takes advantage of the most recent developments in SWIR imaging with an ultra-low-noise InGaAs camera (Alizé 1.7 or ZephIR 1.7), novel homogeneous illumination and powerful analytical software to provide an unprecedented combination of fast, high resolution and deep imaging.

 

Key Feature

  • High spatial resolution
  • High temporal resolution (real-time dynamics)
  • Non-ionizing & non-invasive
  • Good penetration depth (10x greater than traditional visible optical systems).

 

Andor ZL41 Cell sCMOS

Easy & Cost-Effective Super-Resolution to ~ 100 nm

ZL41 Cell builds on the strengths of the original Zyla series: high-speed, high-sensitivity and high-resolution imaging performance. ZL41 Cell is perfectly suited to many experiments that push the boundaries of speed and sensitivity.

Key Applications:

✔️Live cell imaging
✔️Neuroimaging
✔️ Developmental biology
✔️ Cell and tissue imaging
✔️ Calcium imaging
✔️Cell trafficking

Key Specifications:

✔️Sharp: ~100 nm resolution
✔️ Fast: up to 100 fps
✔️Sensitive: up to 82% QE
✔️ Accurate: >99.8% linearity
✔️ Flexible: 4.2 and 5.5 Megapixels
✔️Productive: up to 22 mm field of view

Quality, Throughput, Performance, Accessibility…

✔️High sensitivity & wide dynamic range – quantify very weak and very bright structures with one image.
✔️Superb image quality – high resolution and uniform backgrounds for publication quality imaging.
✔️Capture everything – large field of view matches that of modern microscopes. Achieve better statistics and higher throughout in high content experiments.
✔️Blazingly fast – more and more studies of cell processes require greater temporal resolution. ZL41 Cell is fast and importantly keeps noise low.
✔️Ease of use – start imaging immediately with helpful documentation and features like Python integration in camera SDK.

 

Photon etc – Infrared Microplate Reader (ClaIR™)

Excite your probes at any wavelengths to validate their NIR-II emissions

The ClaIR NIR-II microplate reader is able to capture full fluorescence spectra from 900 nm to 1600 nm and the transmittance spectrum from 500 nm to 1600 nm. Using the included software, the ClaIR plate reader can perform a range of endpoint and kinetic applications. The instrument comes with your preferred laser-based excitation sources, which can be complemented by a high-power tunable light source. An optional benchtop probe is available, extending the capabilities to in vivo measurements.

 

White paper

Photon etc – In Vivo NIR-II Spectral Probe (IRina™)

Quantitate bio-photonic emissions and visualize the spectral shifting of ABS in real-time

The IRina™ in vivo spectral probe can deliver full spectral measurements in the NIR-II range. Ideal for measuring fluorescence emission from nanosensors or new dyes, its small form factor and ergonomic benchtop design allow for easy measurement inside small living animals or thick tissues. Using the included PHySpec™ software, multiple acquisitions and time series are straightforward to acquire and analyze.

 

White paper

Photon etc – Laser Line Tunable Filter (LLTF CONTRAST™)

The Laser Line Tunable Filter (LLTF CONTRAST) is a non-dispersive patented (US patent 7557990) optical tunable bandpass filter based on volume Bragg gratings. It combines very high optical density (> OD6), an outstanding out-of-band rejection, and a wideband tuning range across the visible (VIS) and infrared (NIR, SWIR). The LLTF can be customized to cover the entire 400 nm to 2500 nm spectral range with a high spectral resolution.

It can be coupled with a wide variety of broadband sources, such as supercontinuum, to create a tunable laser source. It can also be used as a cleanup filter for spectroscopy applications.

There are numerous possible LLTF configurations whose spectral range and bandwidth can be finely tuned to fit specific needs. The specifications below of several tried-and-tested standard models may serve as a starting point.

 

White paper

 

White paper

Andor Sona-11 Series

Sona-11: For the Widest Field of View

Sona-11 has the biggest sensor on the market with a full 32 mm sensor diagonal! Andor’s unique technology usefully accesses the entire 2048 x 2048 array offering 62% larger field of view than competing back illuminated cameras. The 95% QE and larger pixel size of 11 µm provides optimal photon collection, for the most light-starved applications. Study structures and processes within the cell in perfect resolution using techniques such as confocal, TIRF and Single Molecule Localization Microscopy (SMLM)

See the full picture: With a 32 mm sensor diagonal Sona-11 has a field of view advantage:
✔️2.9x larger field of view vs typical sCMOS
✔️2.1x larger field of view vs 22 mm format sCMOS
✔️62% larger field of view vs competing back-illuminated sCMOS (1608×1608 array)

✔️Capture weak signals – 95% QE is complemented by large 11 µm pixel
size for optimal photon collection
✔️SRRF-Stream+ Super-Resolution – Transform a standard microscope to super-resolution!
✔️NEW Python ready – Updated camera SDK integrates a Python
wrapper for speedy integration

Key Applications:

  • Developmental biology
  • Neuroimaging
  • Super-resolution
  • Transcriptomics
  • Intracellular trafficking
  • Plasma membrane studies

Photon etc IMA Hyperspectral microscope

Global hyperspectral microscope

IMA is a hyperspectral microscope delivering spectral and spatial information in the VIS, NIR, and SWIR range (400 nm – 1620 nm). This system rapidly maps photoluminescence, electroluminescence, fluorescence, reflectance, and transmittance. Based on high throughput global-imaging filters, IMA is faster and more efficient than standard point-by-point or line-scan based systems.

IMA Applications Overview

  • Perform complex material analyses such as solar cell characterization and semiconductor quality control
  • Study of sample formation, degradation and identification of deficient areas
  • Imaging of multiplexed emitters
  • Access to the second biological window (900 – 1620 nm)
  • Mapping of spectral heterogeneities
  • Study IR markers in complex environments including live cells and tissue.
  • Fast imaging – 1.4 million spectra in minutes
  • Retrieve darkfield images and obtain a contrast of transparent and unstained samples such as polymers, crystals or live cells.

 

Andor Dragonfly 600 Confocal Microscope

Dragonfly High Speed Confocal Microscope System

Dragonfly delivers outstanding multi-dimensional images from subcellular (nm) to whole organism (cm), while significantly boosting productivity.

Its unrivalled combination of speed and sensitivity allows researchers to discover unforeseen dynamic events and image live organisms for days. The new B-TIRF and super resolution modules reveal smaller details, such as the dynamics of viral infection and the ultrastructure of chromatin or organelles.

Dragonfly is a high-contrast multi-dimensional imaging platform capable of four key imaging modalities. At its core is a multi-point confocal for high-speed and high-sensitivity imaging. Capturing at speeds at least 10x faster than conventional confocal technology, with dramatically improved sensitivity from 400-800 nm. Dragonfly is the optimal solution for live cell imaging, providing low phototoxicity and photobleaching, or perfect for fast volume acquisition of fixed samples.

Dragonfly 600 spinning disk confocal delivers leading performance for both industrial and academic users. It integrates super-resolution solutions compatible with confocal, widefield or TIRF. Furthermore, it incorporates the newly developed High Power Laser Engine (HLE) and new TIRF imaging modality, which exploits Borealis® illumination, B-TIRF (Borealis TIRF) for easy setup, more even illumination and thus more usable data across the field of view.

Key Specifications:

✔️Instant confocal: up to 400 fps
✔️Borealis® uniform illumination
✔️3D SMLM: resolution to 10-20 nm
✔️Live cell super-resolution: SRRF-Stream+
✔️Unique easy-to-use TIRF: B-TIRF
✔️Broad wavelength range: UV-Vis to NIR
✔️Greater productivity: large field of view

Key Applications:
✔️Developmental, cell & neurobiology
✔️Cancer & oncobiology
✔️Microbiology & virology
✔️Organoids & large model organisms
✔️Spatial genomics & proteomics
✔️Multiplex & Expansion microscopy
✔️Plant biology

 

 

Photon etc HypIRia SWIR Lenses – 1.0 to 2.9 µm

SWIR Lenses – 1.0 to 2.9 µm

 

The HypIRia are wide-aperture, image-space telecentric lenses precisely crafted to provide clear and bright images in the SWIR spectral range. A broadband anti-reflective coating on carefully selected glass delivers high throughput and low-aberration imaging on a range extending from 1.0 to 2.9 µm.

A translational focus provides excellent stability during focusing. Robustly built, they are well suited for industrial applications or field work.

Three focal lengths are currently available.